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Observed performance metrics in laboratory models
Observed performance metrics in laboratory models
Research summary on YK-11 (also known as Myostatin Inhibitor YK-11).
YK-11 is a Selective Androgen Receptor Modulator (SARM)
YK-11 is a Selective Androgen Receptor Modulator (SARM) — unique for also acting as a myostatin inhibitor, potentially unlocking greater muscle growth.
In research settings, it has been shown to:
✔ Increase muscle cell differentiation and size.
✔ Reduce myostatin activity in muscle tissue.
✔ Support rapid strength development.
🚫 MYOSTATIN INHIBITION:
YK-11’s ability to down regulate myostatin expression may allow for greater muscle hypertrophy than SARMs without this effect.
⚡ ACCELERATED STRENGTH:
Research models indicate faster increases in muscular strength compared to baseline.
📈 CELLULAR GROWTH:
By promoting follistatin expression, YK-11 supports muscle cell development and repair.
1. Harding, Caitlin, Viljanto, Marjaana, Habershon-Butcher, Jocelyn, Taylor, Polly, & Scarth, James (2023). Equine metabolism of the selective androgen receptor modulator YK-11 in urine and plasma following oral administration.. Drug testing and analysis.
https://doi.org/10.1002/dta.3425
2. Jeong, Ji-Ho, Kim, Minseon, & Kim, Yongae (2021). NMR structural studies and mechanism of action of Lactophoricin analogs as antimicrobial peptides.. Biochimica et biophysica acta. Biomembranes.
Research summary on Testolone (also known as RAD-140).
RAD 140, also known as Testolone, is a non-steroidal selective androgen receptor modulator.
RAD-140 (Testolone) is a Selective Androgen Receptor Modulator (SARM) — studied for its high anabolic-to-androgenic ratio and potential neuroprotective benefits.
In research settings, it has been shown to:
✔ Stimulate significant muscle growth.
✔ Enhance strength and power output.
✔Exhibit neuroprotective effects in research models.
📏 LEAN MUSCLE RETENTION:
RAD-140 has been observed to induce robust gains in lean muscle mass, even at low research dosages.
⚡ PERFORMANCE ENHANCEMENT:
Its anabolic effects contribute to improvements in maximal strength and explosive power.
🧩 BRAIN HEALTH:
Animal studies suggest RAD-140 may offer neuroprotective benefits by reducing cell death in neurons.
Design, Synthesis, and Preclinical Characterization of RAD140 — ACS Medicinal Chemistry Letters (2011).
https://exaly.com/paper-pdf/51248120/citation-report.pdf
Selective Androgen Receptor Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats — Endocrinology (2014).
https://healthedacademy.com/rad-140-vs-rad-150/
Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor–Positive Breast Cancer Models — Clinical Cancer Research (2017).
Phase I Dose-Escalation Study of the Selective AR Modulator RAD140 in Metastatic Breast Cancer — Annals of Oncology (2019 abstract; full paper later in Clinical Breast Cancer, 2022).
https://www.annalsofoncology.org/article/S0923-7534%2819%2958565-9/fulltext
Research summary on LGD-4 (also known as Ligandrol or VK-5211).
LGD-4, also known as Ligandrol or VK5211, is a research compound classified as a selective androgen receptor modulator (SARM).
Ligandrol is a Selective Androgen Receptor Modulator (SARM) — known for its potent anabolic activity in muscle and bone tissue.
In research settings, it has been shown to:
✔ Increase lean body mass even at low doses.
✔ Enhance muscle strength and endurance capacity.
✔ Aid recovery from musculoskeletal injury.
💥 MUSCLE HYPERTROPHY:
Clinical studies have shown Ligandrol to significantly increase lean muscle mass in healthy adults within just weeks of administration.
🪨 STRENGTH GAINS:
Participants in research trials have demonstrated measurable improvements in lifting strength and muscular endurance.
🔄 RECOVERY SUPPORT:
By promoting anabolic signaling, Ligandrol can aid in tissue repair following injury or intense training.
1.Angelis, Yiannis S, Sakellariou, Panagiotis, Petrou, Michael, & Pitsinos, Emmanuel N (2024). Targeted Metabolic Investigation of Ligandrol and Analytical Methods Validation for Its Main Long-term Metabolite.. ChemPlusChem.
https://doi.org/10.1002/cplu.202300634
2. Basaria, Shehzad, Collins, Lauren, Dillon, E Lichar, Orwoll, Katie, Storer, Thomas W, Miciek, Renee, ... Bhasin, Shalender (2013). The safety, pharmacokinetics, and effects of Ligandrol, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men.. The journals of gerontology. Series A, Biological sciences and medical sciences.
https://doi.org/10.1093/gerona/gls078
3. Breuer, Johanna, Thomas, Andreas, Delahaut, Philippe, Schänzer, Wilhelm, Geyer, Hans, & Thevis, Mario (2023). Investigations into the concentration and metabolite profiles of stanozolol and Ligandrol in blood plasma and seminal fluid using liquid chromatography high-resolution mass spectrometry.. Analytical and bioanalytical chemistry.
https://doi.org/10.1007/s00216-022-04456-y
4. Cox, Holly D, & Eichner, Daniel (2017). Detection of Ligandrol and its metabolites in athlete urine samples.. Drug testing and analysis.
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